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The influence of the microenvironment on the malignant phenotypeNormal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. As tissue becomes cancerous, there are reciprocal interactions between neoplastic cells, adjacent normal cells such as stroma and endothelium, and their microenvironments. The current dominant paradigm wherein multiple genetic lesions provide both the impetus for, and the Achilles heel of, cancer might be inadequate to understand cancer as a disease process. In the following brief review, we will use selected examples to illustrate the influence of the microenvironment in the evolution of the malignant phenotype. We will also discuss recent studies that suggest novel therapeutic interventions might be derived from focusing on microenvironment and tumor cells interactions.
Document ID
20040131990
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Park, C. C.
(Harvard Medical School Boston, MA, United States)
Bissell, M. J.
Barcellos-Hoff, M. H.
Date Acquired
August 22, 2013
Publication Date
August 1, 2000
Publication Information
Publication: Molecular medicine today
Volume: 6
Issue: 8
ISSN: 1357-4310
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review, Tutorial
NASA Discipline Radiation Health
Review

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