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Mechanical control of cyclic AMP signalling and gene transcription through integrinsThis study was carried out to discriminate between two alternative hypotheses as to how cells sense mechanical forces and transduce them into changes in gene transcription. Do cells sense mechanical signals through generalized membrane distortion or through specific transmembrane receptors, such as integrins? Here we show that mechanical stresses applied to the cell surface alter the cyclic AMP signalling cascade and downstream gene transcription by modulating local release of signals generated by activated integrin receptors in a G-protein-dependent manner, whereas distortion of integrins in the absence of receptor occupancy has no effect.
Document ID
20040141407
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Meyer, C. J. (Children's Hospital and Harvard Medical School Boston, Massachusetts 02115, United States)
Alenghat, F. J.
Rim, P.
Fong, J. H.
Fabry, B.
Ingber, D. E.
Date Acquired
August 22, 2013
Publication Date
September 1, 2000
Publication Information
Publication: Nature cell biology
Volume: 2
Issue: 9
ISSN: 1465-7392
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL33009
CONTRACT_GRANT: CA55833
CONTRACT_GRANT: DE00275
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
Non-NASA Center