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Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in DrosophilaThe senseless (sens) gene is required for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS) of Drosophila. Sens is a nuclear protein with four Zn fingers that is expressed and required in the sensory organ precursors (SOP) for proper proneural gene expression. Ectopic expression of Sens in many ectodermal cells causes induction of PNS external sensory organ formation and is able to recreate an ectopic proneural field. Hence, sens is both necessary and sufficient for PNS development. Our data indicate that proneural genes activate sens expression. Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs.
Document ID
20040141410
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nolo, R.
(Howard Hughes Medical Institute, Baylor College of Medicine Houston, Texas 77030, United States)
Abbott, L. A.
Bellen, H. J.
Date Acquired
August 22, 2013
Publication Date
August 4, 2000
Publication Information
Publication: Cell
Volume: 102
Issue: 3
ISSN: 0092-8674
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Developmental Biology
Non-NASA Center

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