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A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouseWe have studied the efficiency of DNA double strand break (DSB) rejoining in primary cells from mouse strains that show large differences in in vivo radiosensitivity and tumor susceptibility. Cells from radiosensitive, cancer-prone BALB/c mice showed inefficient end joining of gamma ray-induced DSBs as compared with cells from all of the other commonly used strains and F1 hybrids of C57BL/6 and BALB/c mice. The BALB/c repair phenotype was accompanied by a significantly reduced expression level of DNA-PKcs protein as well as a lowered DNA-PK activity level as compared with the other strains. In conjunction with published reports, these data suggest that natural genetic variation in nonhomologous end joining processes may have a significant impact on the in vivo radiation response of mice.
Document ID
20040141414
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Okayasu, R.
(Colorado State University Fort Collins 80523-1673, United States)
Suetomi, K.
Yu, Y.
Silver, A.
Bedford, J. S.
Cox, R.
Ullrich, R. L.
Date Acquired
August 22, 2013
Publication Date
August 15, 2000
Publication Information
Publication: Cancer research
Volume: 60
Issue: 16
ISSN: 0008-5472
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: CA43322
CONTRACT_GRANT: CA71438
CONTRACT_GRANT: CA73729
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Radiation Health

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