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Growth of Steptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin productionGrowth of Streptomyces hygroscopicus under conditions of simulated microgravity in a rotating-wall bioreactor resulted in a pellet form of growth, lowered dry cell weight, and inhibition of rapamycin production. With the addition of Teflon beads to the bioreactor, growth became much less pelleted, dry cell weight increased but rapamycin production was still markedly inhibited. Growth under simulated microgravity favored extracellular production of rapamycin, in contrast to a greater percentage of cell-bound rapamycin observed under normal gravity conditions.
Document ID
20040141432
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Fang, A.
(Massachusetts Institute of Technology Cambridge 02139, United States)
Pierson, D. L.
Mishra, S. K.
Demain, A. L.
Date Acquired
August 22, 2013
Publication Date
July 1, 2000
Publication Information
Publication: Applied microbiology and biotechnology
Volume: 54
Issue: 1
ISSN: 0175-7598
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center JSC
NASA Discipline Environmental Health

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