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Prolonged fasting increases the response of the renin-angiotensin-aldosterone system, but not vasopressin levels, in postweaned northern elephant seal pupsThe 8- to 12-week postweaning fast exhibited by northern elephant seal pups (Mirounga angustirostris) occurs without any apparent deleterious effects on fluid and electrolyte homeostasis. However, during the fast the role of vasopressin (AVP) has been shown to be inconclusive and the involvement of the renin-angiotensin-aldosterone system (RAAS) has yet to be examined. To examine the effects of prolonged fasting on these osmoregulatory hormones, 15 postweaned pups were serially blood-sampled during the first 49 days of their fast. Fasting did not induce significant changes in ionic or osmotic concentrations, suggesting electrolyte homeostasis. Total proteins were reduced by day 21 of fasting and remained depressed, suggesting a lack of dehydration. Aldosterone and plasma renin activity exhibited a correlated, linear increase over the first 49 days of the fast, suggesting an active RAAS. Aldosterone exhibited a parabolic trend over the fast with a peak at day 35, suggesting a shift in the sensitivity of the kidney to aldosterone later in the fast. AVP was elevated at day 49 only, but concentrations were relatively low. RAAS was modified during the postweaning fast in pups and appears to play a significant role in the regulation of electrolyte and, most likely, water homeostasis during this period. Copyright 2000 Academic Press.
Document ID
20040141453
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Ortiz, R. M. (University of California Santa Cruz, California, 95064, United States)
Wade, C. E.
Ortiz, C. L.
Date Acquired
August 22, 2013
Publication Date
August 1, 2000
Publication Information
Publication: General and comparative endocrinology
Volume: 119
Issue: 2
ISSN: 0016-6480
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: GM 58903-01
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
NASA Center ARC