NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Neocortical malformation as consequence of nonadaptive regulation of neuronogenetic sequenceVariations in the structure of the neocortex induced by single gene mutations may be extreme or subtle. They differ from variations in neocortical structure encountered across and within species in that these "normal" structural variations are adaptive (both structurally and behaviorally), whereas those associated with disorders of development are not. Here we propose that they also differ in principle in that they represent disruptions of molecular mechanisms that are not normally regulatory to variations in the histogenetic sequence. We propose an algorithm for the operation of the neuronogenetic sequence in relation to the overall neocortical histogenetic sequence and highlight the restriction point of the G1 phase of the cell cycle as the master regulatory control point for normal coordinate structural variation across species and importantly within species. From considerations based on the anatomic evidence from neocortical malformation in humans, we illustrate in principle how this overall sequence appears to be disrupted by molecular biological linkages operating principally outside the control mechanisms responsible for the normal structural variation of the neocortex. MRDD Research Reviews 6:22-33, 2000. Copyright 2000 Wiley-Liss, Inc.
Document ID
20040141477
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Caviness, V. S. Jr
(Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts 02114, United States)
Takahashi, T.
Nowakowski, R. S.
Date Acquired
August 22, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Mental retardation and developmental disabilities research reviews
Volume: 6
Issue: 1
ISSN: 1080-4013
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS12005
CONTRACT_GRANT: NS33433
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial
NASA Discipline Cell Biology
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available