NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosisAmyotrophic lateral sclerosis (ALS) is a disorder marked by loss of motoneurons. We hypothesized that subjects with ALS would have an altered gait rhythm, with an increase in both the magnitude of the stride-to-stride fluctuations and perturbations in the fluctuation dynamics. To test for this locomotor instability, we quantitatively compared the gait rhythm of subjects with ALS with that of normal controls and with that of subjects with Parkinson's disease (PD) and Huntington's disease (HD), pathologies of the basal ganglia. Subjects walked for 5 min at their usual pace wearing an ankle-worn recorder that enabled determination of the duration of each stride and of stride-to-stride fluctuations. We found that the gait of patients with ALS is less steady and more temporally disorganized compared with that of healthy controls. In addition, advanced ALS, HD, and PD were associated with certain common, as well as apparently distinct, features of altered stride dynamics. Thus stride-to-stride control of gait rhythm is apparently compromised with ALS. Moreover, a matrix of markers based on gait dynamics may be useful in characterizing certain pathologies of motor control and, possibly, in quantitatively monitoring disease progression and evaluating therapeutic interventions.
Document ID
20040141530
Document Type
Reprint (Version printed in journal)
Authors
Hausdorff, J. M. (Beth Israel Deaconess Medical Center Boston, MA 02215, United States)
Lertratanakul, A.
Cudkowicz, M. E.
Peterson, A. L.
Kaliton, D.
Goldberger, A. L.
Date Acquired
August 22, 2013
Publication Date
June 1, 2000
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 88
Issue: 6
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AG-14100
CONTRACT_GRANT: AG-08812
CONTRACT_GRANT: AG-00294
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Biomedical Research and Countermeasures
NASA Discipline Cardiopulmonary
Non-NASA Center