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Genetic dissection of cardiac growth control pathwaysCardiac muscle cells exhibit two related but distinct modes of growth that are highly regulated during development and disease. Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle irreversibly soon after birth, following which the predominant form of growth shifts from hyperplastic to hypertrophic. Much research has focused on identifying the candidate mitogens, hypertrophic agonists, and signaling pathways that mediate these processes in isolated cells. What drives the proliferative growth of embryonic myocardium in vivo and the mechanisms by which adult cardiac myocytes hypertrophy in vivo are less clear. Efforts to answer these questions have benefited from rapid progress made in techniques to manipulate the murine genome. Complementary technologies for gain- and loss-of-function now permit a mutational analysis of these growth control pathways in vivo in the intact heart. These studies have confirmed the importance of suspected pathways, have implicated unexpected pathways as well, and have led to new paradigms for the control of cardiac growth.
Document ID
20040141538
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
MacLellan, W. R.
(UCLA School of Medicine 90076 United States)
Schneider, M. D.
Date Acquired
August 22, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Annual review of physiology
Volume: 62
ISSN: 0066-4278
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Biomedical Research and Countermeasures
NASA Discipline Cardiopulmonary
Review
Non-NASA Center
Review, Tutorial

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