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Orthostatic intolerance: a disorder of young womenOrthostatic intolerance (OI) is a cause of significant disability in otherwise healthy women seen by gynecologists. Orthostatic tachycardia is often the most obvious hemodynamic abnormality found in OI patients, but symptoms may include dizziness, visual changes, discomfort in the head or neck, poor concentration, fatigue, palpitations, tremulousness, anxiety, and, in some cases, fainting (syncope). It is the most common disorder of blood pressure regulation after essential hypertension, and patients with OI are traditionally women of childbearing age. Estimates suggest that at least 500,000 Americans suffer from some form of OI, and such patients comprise the largest group referred to centers specialized in autonomic disorders. This article reviews recent advances made in the understanding of this condition, potential pathophysiological mechanisms contributing to orthostatic intolerance, and therapeutic alternatives currently available for the management of these patients.
Document ID
20040141607
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ali, Y. S.
(Vanderbilt University Nashville, Tennessee 37232-2195, United States)
Daamen, N.
Jacob, G.
Jordan, J.
Shannon, J. R.
Biaggioni, I.
Robertson, D.
Date Acquired
August 22, 2013
Publication Date
April 1, 2000
Publication Information
Publication: Obstetrical & gynecological survey
Volume: 55
Issue: 4
ISSN: 0029-7828
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: 1U01 NS33460
CONTRACT_GRANT: RR00095
CONTRACT_GRANT: PO1 HL56693
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Non-NASA Center
NASA Discipline Regulatory Physiology
Review

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