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Record 17 of 139
Analysis of shape and motion of the mitral annulus in subjects with and without cardiomyopathy by echocardiographic 3-dimensional reconstruction
External Online Source: doi:10.1067/mje.2000.103878
Author and Affiliation:
Flachskampf, F. A.(Departments of Cardiology and Biomedical Engineering, Cleveland Clinic Foundation, OH, United States)
Chandra, S.
Gaddipatti, A.
Levine, R. A.
Weyman, A. E.
Ameling, W.
Hanrath, P.
Thomas, J. D.
Abstract: The shape and dynamics of the mitral annulus of 10 patients without heart disease (controls), 3 patients with dilated cardiomyopathy, and 5 patients with hypertrophic obstructive cardiomyopathy and normal systolic function were analyzed by transesophageal echocardiography and 3-dimensional reconstruction. Mitral annular orifice area, apico-basal motion of the annulus, and nonplanarity were calculated over time. Annular area was largest in end diastole and smallest in end systole. Mean areas were 11.8 +/- 2.5 cm(2) (controls), 15.2 +/- 4.2 cm(2) (dilated cardiomyopathy), and 10.2 +/- 2.4 cm(2) (hypertrophic cardiomyopathy) (P = not significant). After correction for body surface, annuli from patients with normal left ventricular function were smaller than annuli from patients with dilated cardiomyopathy (5.9 +/- 1.2 cm(2)/m(2) vs 7.7 +/- 1.0 cm(2)/m(2); P <.02). The change in area during the cardiac cycle showed significant differences: 23.8% +/- 5.1% (controls), 13.2% +/- 2.3% (dilated cardiomyopathy), and 32.4% +/- 7.6% (hypertrophic cardiomyopathy) (P <.001). Apico-basal motion was highest in controls, followed by those with hypertrophic obstructive and dilated cardiomyopathy (1.0 +/- 0.3 cm, 0.8 +/- 0.2 cm, 0.3 +/- 0.2 cm, respectively; P <.01). Visual inspection and Fourier analysis showed a consistent pattern of anteroseptal and posterolateral elevations of the annulus toward the left atrium. In conclusion, although area changes and apico-basal motion of the mitral annulus strongly depend on left ventricular systolic function, nonplanarity is a structural feature preserved throughout the cardiac cycle in all three groups.
Publication Date: Apr 01, 2000
Document ID:
20040141611
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (ISSN 0894-7317); Volume 13; 4; 277-87
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ECHOCARDIOGRAPHY; HEART DISEASES; HEART FUNCTION; HEART VALVES; SHAPES; ADULTS; AGE FACTOR; CARDIAC VENTRICLES; PATHOLOGY
Other Descriptors: CARDIOMYOPATHY, CONGESTIVE/PHYSIOPATHOLOGY/ULTRASONOGRAPHY; CARDIOMYOPATHY, HYPERTROPHIC/PHYSIOPATHOLOGY/ULTRASONOGRAPHY; ECHOCARDIOGRAPHY, THREE-DIMENSIONAL; ECHOCARDIOGRAPHY, TRANSESOPHAGEAL; MITRAL VALVE/PHYSIOLOGY/ULTRASONOGRAPHY; ADULT; AGED; HUMAN; MIDDLE AGED; SUPPORT, NON-U.S. GOV'T; VENTRICULAR FUNCTION, LEFT/PHYSIOLOGY; NASA DISCIPLINE CARDIOPULMONARY; NASA PROGRAM BIOMEDICAL RESEARCH AND COUNTERMEASURES; NON-NASA CENTER
Availability Source: Other Sources
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