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Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotidesAltritol nucleic acids (ANAs) are RNA analogues with a phosphorylated D-altritol backbone. The nucleobase is attached at the 2-(S)-position of the carbohydrate moiety. We report that ANA oligomers are superior to the corresponding DNA, RNA, and HNA (hexitol nucleic acid) in supporting efficient nonenzymatic template-directed synthesis of complementary RNAs from nucleoside-5'-phosphoro-2-methyl imidazolides. Activated ANA and HNA monomers do not oligomerize efficiently on DNA, RNA, HNA, or ANA templates.
Document ID
20040141622
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kozlov, I. A.
(The Salk Institute for Biological Studies San Diego, California 92186, United States)
Zielinski, M.
Allart, B.
Kerremans, L.
Van Aerschot, A.
Busson, R.
Herdewijn, P.
Orgel, L. E.
Bada, J. L.
Date Acquired
August 22, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Chemistry (Weinheim an der Bergstrasse, Germany)
Volume: 6
Issue: 1
ISSN: 0947-6539
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology

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