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Regional ventilation-perfusion distribution is more uniform in the prone positionThe arterial blood PO(2) is increased in the prone position in animals and humans because of an improvement in ventilation (VA) and perfusion (Q) matching. However, the mechanism of improved VA/Q is unknown. This experiment measured regional VA/Q heterogeneity and the correlation between VA and Q in supine and prone positions in pigs. Eight ketamine-diazepam-anesthetized, mechanically ventilated pigs were studied in supine and prone positions in random order. Regional VA and Q were measured using fluorescent-labeled aerosols and radioactive-labeled microspheres, respectively. The lungs were dried at total lung capacity and cubed into 603-967 small ( approximately 1.7-cm(3)) pieces. In the prone position the homogeneity of the ventilation distribution increased (P = 0.030) and the correlation between VA and Q increased (correlation coefficient = 0.72 +/- 0.08 and 0.82 +/- 0.06 in supine and prone positions, respectively, P = 0.03). The homogeneity of the VA/Q distribution increased in the prone position (P = 0.028). We conclude that the improvement in VA/Q matching in the prone position is secondary to increased homogeneity of the VA distribution and increased correlation of regional VA and Q.
Document ID
20040141643
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mure, M.
(Karolinska Hospital and Institute SE-171 76 Stockholm, Sweden)
Domino, K. B.
Lindahl, S. G.
Hlastala, M. P.
Altemeier, W. A.
Glenny, R. W.
Date Acquired
August 22, 2013
Publication Date
March 1, 2000
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 88
Issue: 3
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL-24163
CONTRACT_GRANT: HL-12174
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Biomedical Research and Countermeasures
NASA Discipline Cardiopulmonary
Non-NASA Center

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