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Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together?Substantial death of migrating and differentiating neurons occurs within the developing CNS of mice that are deficient in genes required for repair of double-stranded DNA breaks. These findings suggest that large-scale, yet previously unrecognized, double-stranded DNA breaks occur normally in early postmitotic and differentiating neurons. Moreover, they imply that cell death occurs if the breaks are not repaired. The cause and natural function of such breaks remains a mystery; however, their occurrence has significant implications. They might be detected by histological methods that are sensitive to DNA fragmentation and mistakenly interpreted to indicate cell death when no relationship exists. In a broader context, there is now renewed speculation that DNA recombination might be occurring during neuronal development, similar to DNA recombination in developing lymphocytes. If this is true, the target gene(s) of recombination and their significance remain to be determined.
Document ID
20040141666
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gilmore, E. C.
(School of Medicine, Case Western Reserve University, University Hospitals of Cleveland Cleveland, OH 44106, United States)
Nowakowski, R. S.
Caviness, V. S. Jr
Herrup, K.
Date Acquired
August 22, 2013
Publication Date
March 1, 2000
Publication Information
Publication: Trends in neurosciences
Volume: 23
Issue: 3
ISSN: 0166-2236
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS33433
CONTRACT_GRANT: NS 20591
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
Non-NASA Center
Review, Tutorial
Review

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