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Independent controls for neocortical neuron production and histogenetic cell deathWe estimated the proportion of cells eliminated by histogenetic cell death during the first 2 postnatal weeks in areas 1, 3 and 40 of the mouse parietal neocortex. For each layer and for the subcortical white matter in each neocortical area, the number of dying cells per mm(2) was calculated and the proportionate cell death for each day of the 2-week interval was estimated. The data show that cell death proceeds essentially uniformly across the neocortical areas and layers and that it does not follow either the spatiotemporal gradient of cell cycle progression in the pseudostratified ventricular epithelium of the cerebral wall, the source of neocortical neurons, or the 'inside-out' neocortical neuronogenetic sequence. Therefore, we infer that the control mechanisms of neocortical histogenetic cell death are independent of mechanisms controlling neuronogenesis or neuronal migration but may be associated with the ingrowth, expansion and a system-wide matching of neuronal connectivity. Copyright 2000 S. Karger AG, Basel.
Document ID
20040141686
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Verney, C.
(Massachusetts General Hospital, Harvard Medical School Boston, Mass., United States)
Takahashi, T.
Bhide, P. G.
Nowakowski, R. S.
Caviness, V. S. Jr
Date Acquired
August 22, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Developmental neuroscience
Volume: 22
Issue: 2-Jan
ISSN: 0378-5866
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS33433
CONTRACT_GRANT: NS12005
CONTRACT_GRANT: NS32657
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
Non-NASA Center

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