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Record 1 of 6914
Independent controls for neocortical neuron production and histogenetic cell death
External Online Source: doi:10.1159/000017434
Author and Affiliation:
Verney, C.(Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Boston, Mass., United States)
Takahashi, T.
Bhide, P. G.
Nowakowski, R. S.
Caviness, V. S. Jr
Abstract: We estimated the proportion of cells eliminated by histogenetic cell death during the first 2 postnatal weeks in areas 1, 3 and 40 of the mouse parietal neocortex. For each layer and for the subcortical white matter in each neocortical area, the number of dying cells per mm(2) was calculated and the proportionate cell death for each day of the 2-week interval was estimated. The data show that cell death proceeds essentially uniformly across the neocortical areas and layers and that it does not follow either the spatiotemporal gradient of cell cycle progression in the pseudostratified ventricular epithelium of the cerebral wall, the source of neocortical neurons, or the 'inside-out' neocortical neuronogenetic sequence. Therefore, we infer that the control mechanisms of neocortical histogenetic cell death are independent of mechanisms controlling neuronogenesis or neuronal migration but may be associated with the ingrowth, expansion and a system-wide matching of neuronal connectivity. Copyright 2000 S. Karger AG, Basel.
Publication Date: Jan 01, 2000
Document ID:
20040141686
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Developmental neuroscience (ISSN 0378-5866); Volume 22; 1-2; 125-38
Publisher Information: Switzerland
Contract/Grant/Task Num: NS12005; NS32657; NS33433
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: APOPTOSIS; CEREBRAL CORTEX; CYTOLOGY; DEATH; NEURONS; ANIMALS; CELL DIVISION; MICE
Other Descriptors: APOPTOSIS/PHYSIOLOGY; NEOCORTEX/CYTOLOGY; NEURONS/CYTOLOGY/PHYSIOLOGY; ANIMALS; ANIMALS, NEWBORN/PHYSIOLOGY; CELL CYCLE/PHYSIOLOGY; CELL DEATH/PHYSIOLOGY; CELL DIVISION/PHYSIOLOGY; IN SITU NICK-END LABELING; MICE; MICE, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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