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Incomplete segregation of endorgan-specific vestibular ganglion cells in mice and ratsThe endorgan-specific distribution of vestibular ganglion cells was studied in neonatal and postnatal rats and mice using indocarbocyanine dye (DiI) and dextran amines for retrograde and anterograde labeling. Retrograde DiI tracing from the anterior vertical canal labeled neurons scattered throughout the whole superior vestibular ganglion, with denser labeling at the dorsal and central regions. Horizontal canal neurons were scattered along the dorsoventral axis with more clustering toward the dorsal and ventral poles of this axis. Utricular ganglion cells occupied predominantly the central region of the superior vestibular ganglion. This utricular population overlapped with both the anterior vertical and horizontal canals' ganglion cells. Posterior vertical canal neurons were clustered in the posterior part of the inferior vestibular ganglion. The saccular neurons were distributed in the two parts of the vestibular ganglion, the superior and inferior ganglia. Within the inferior ganglion, the saccular neurons were clustered in the anterior part. In the superior ganglion, the saccular neurons were widely scattered throughout the whole ganglion with more numerous neurons at the posterior half. Small and large neurons were labeled from all endorgans. Examination of the fiber trajectory within the superior division of the vestibular nerve showed no clear lamination of the fibers innervating the different endorgans. These results demonstrate an overlapping pattern between the different populations within the superior ganglion, while in the inferior ganglion, the posterior canal and saccular neurons show tighter clustering but incomplete segregation. This distribution implies that the ganglion cells are assigned for their target during development in a stochastic rather than topographical fashion.
Document ID
20040141696
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Maklad, A.
(Creighton University, Dept. of Biomedical Sciences Omaha, NE 68178, United States)
Fritzsch, B.
Date Acquired
August 22, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Journal of vestibular research : equilibrium & orientation
Volume: 9
Issue: 6
ISSN: 0957-4271
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 2 P01 DC00215-14A1
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Developmental Biology
Non-NASA Center
NASA Program Fundamental Space Biology

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