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Chronic recording of regenerating VIIIth nerve axons with a sieve electrodeA micromachined silicon substrate sieve electrode was implanted within transected toadfish (Opsanus tau) otolith nerves. High fidelity, single unit neural activity was recorded from seven alert and unrestrained fish 30 to 60 days after implantation. Fibrous coatings of genetically engineered bioactive protein polymers and nerve guide tubes increased the number of axons regenerating through the electrode pores when compared with controls. Sieve electrodes have potential as permanent interfaces to the nervous system and to bridge missing connections between severed or damaged nerves and muscles. Recorded impulses might also be amplified and used to control prosthetic devices.
Document ID
20040141699
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mensinger, A. F.
(Washington University School of Medicine St. Louis, Missouri 63110, United States)
Anderson, D. J.
Buchko, C. J.
Johnson, M. A.
Martin, D. C.
Tresco, P. A.
Silver, R. B.
Highstein, S. M.
Date Acquired
August 22, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Journal of neurophysiology
Volume: 83
Issue: 1
ISSN: 0022-3077
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS-5-2322
CONTRACT_GRANT: R21-RR-12623
CONTRACT_GRANT: P41 RR-09754-04
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Neuroscience
Non-NASA Center

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