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Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis seraIn sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.
Document ID
20040141701
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mosier, D. R.
(Baylor College of Medicine Houston, TX 77030, United States)
Siklos, L.
Appel, S. H.
Date Acquired
August 22, 2013
Publication Date
January 11, 2000
Publication Information
Publication: Neurology
Volume: 54
Issue: 1
ISSN: 0028-3878
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS33186
CONTRACT_GRANT: NS01859
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Biomedical Research and Countermeasures
NASA Discipline Musculoskeletal
Non-NASA Center

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