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Peptide-formation on cysteine-containing peptide scaffoldsMonomeric cysteine residues attached to cysteine-containing peptides by disulfide bonds can be activated by carbonyldiimidazole. If two monomeric cysteine residues, attached to a 'scaffold' peptide Gly-Cys-Glyn-Cys-Glu10, (n = 0, 1, 2, 3) are activated, they react to form the dipeptide Cys-Cys. in 25-65% yield. Similarly, the activation of a cysteine residue attached to the 'scaffold' peptide Gly-Cys-Gly-Glu10 in the presence of Arg5 leads to the formation of Cys-Arg5 in 50% yield. The significance of these results for prebiotic chemistry is discussed.
Document ID
20040141764
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Chu, B. C. (Salk Institute for Biological Studies San Diego, CA 92186-5800, United States)
Orgel, L. E.
Date Acquired
August 22, 2013
Publication Date
October 1, 1999
Publication Information
Publication: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
Volume: 29
Issue: 5
ISSN: 0169-6149
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Exobiology
Non-NASA Center