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Protein machines and self assembly in muscle organizationThe remarkable order of striated muscle is the result of a complex series of protein interactions at different levels of organization. Within muscle, the thick filament and its major protein myosin are classical examples of functioning protein machines. Our understanding of the structure and assembly of thick filaments and their organization into the regular arrays of the A-band has recently been enhanced by the application of biochemical, genetic, and structural approaches. Detailed studies of the thick filament backbone have shown that the myosins are organized into a tubular structure. Additional protein machines and specific myosin rod sequences have been identified that play significant roles in thick filament structure, assembly, and organization. These include intrinsic filament components, cross-linking molecules of the M-band and constituents of the membrane-cytoskeleton system. Muscle organization is directed by the multistep actions of protein machines that take advantage of well-established self-assembly relationships. Copyright 1999 John Wiley & Sons, Inc.
Document ID
20040141820
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Barral, J. M.
(Baylor College of Medicine Houston, Texas 77030, United States)
Epstein, H. F.
Date Acquired
August 22, 2013
Publication Date
October 1, 1999
Publication Information
Publication: BioEssays : news and reviews in molecular, cellular and developmental biology
Volume: 21
Issue: 10
ISSN: 0265-9247
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Review
Non-NASA Center
Review, Tutorial

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