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EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep lossThe aim of this study was to quantify the associations between slow eye movements (SEMs), eye blink rate, waking electroencephalogram (EEG) power density, neurobehavioral performance, and the circadian rhythm of plasma melatonin in a cohort of 10 healthy men during up to 32 h of sustained wakefulness. The time course of neurobehavioral performance was characterized by fairly stable levels throughout the first 16 h of wakefulness followed by deterioration during the phase of melatonin secretion. This deterioration was closely associated with an increase in SEMs. Frontal low-frequency EEG activity (1-7 Hz) exhibited a prominent increase with time awake and little circadian modulation. EEG alpha activity exhibited circadian modulation. The dynamics of SEMs and EEG activity were phase locked to changes in neurobehavioral performance and lagged the plasma melatonin rhythm. The data indicate that frontal areas of the brain are more susceptible to sleep loss than occipital areas. Frontal EEG activity and ocular parameters may be used to monitor and predict changes in neurobehavioral performance associated with sleep loss and circadian misalignment.
Document ID
20040141832
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Cajochen, C.
(Brigham & Women's Hospital, Harvard Medical School Boston, Massachusetts 02115, United States)
Khalsa, S. B.
Wyatt, J. K.
Czeisler, C. A.
Dijk, D. J.
Date Acquired
August 22, 2013
Publication Date
September 1, 1999
Publication Information
Publication: The American journal of physiology
Volume: 277
Issue: 3 Pt 2
ISSN: 0002-9513
Subject Category
Behavioral Sciences
Funding Number(s)
CONTRACT_GRANT: M01 RR-02635
CONTRACT_GRANT: F33-HL-09588
CONTRACT_GRANT: RO1 MH-45130
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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