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Record 2 of 14
Attenuation of the protein wasting associated with bed rest by branched-chain amino acids
External Online Source: doi:10.1016/S0899-9007(99)00120-3
Author and Affiliation:
Stein, T. P.(University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Department of Surgery, Stratford 08084, United States)
Schluter, M. D.
Leskiw, M. J.
Boden, G.
Abstract: Bed rest is generally accepted as being an appropriate ground-based model for human spaceflight. The objectives of this study were to test the hypothesis that increasing the amount of branched-chain amino acids (BCAAs) in the diet could attenuate the protein loss associated with bed rest. Nineteen healthy subjects were randomized into two groups according to diet. During the 6 d of bed rest, the diets were supplemented with either 30 mmol/d each of three non-essential amino acids, glycine, serine, and alanine (control group), or with 30 mmol/d each of the BCAAs, leucine, isoleucine, and valine (BCAA group). Nutrition was supplied as a commercially available defined formula diet at a rate of 1.3 x REE. Nitrogen (N) balance and urinary 3-MeH excretion were determined for the 6 d. In our results, the urine-based estimate of N balance was 22.2 +/- 14.4 (n = 9) mg N.kg-1.d-1 and 60.5 +/- 10.1 mg (n = 8) N.kg-1.d-1 for the control and BCAA-supplemented groups, respectively (P < 0.05). Urinary 3-MeH excretion was unchanged in both groups with bed rest. We conclude that BCAA supplementation attenuates the N loss during short-term bed rest.
Publication Date: Sep 01, 1999
Document ID:
20040141847
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Nutrition (Burbank, Los Angeles County, Calif.) (ISSN 0899-9007); Volume 15; 9; 656-60
Publisher Information: United States
Contract/Grant/Task Num: R01 AA 10221; RO1 AG 07988; RO1 AG14078
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AMINO ACIDS; BED REST; MUSCLES; PROTEINS; ADULTS; FEMALES; FOOD; LEUCINE; MALES; METABOLISM; NITROGEN
Other Descriptors: AMINO ACIDS, BRANCHED-CHAIN/ADMINISTRATION & DOSAGE/THERAPEUTIC USE; BED REST/ADVERSE EFFECTS; MUSCLE PROTEINS/METABOLISM; WASTING SYNDROME/DIET THERAPY; ADULT; AMINO ACIDS/METABOLISM; ENERGY METABOLISM; FEMALE; FOOD, FORMULATED; HUMAN; ISOLEUCINE/ADMINISTRATION & DOSAGE; LEUCINE/ADMINISTRATION & DOSAGE; MALE; METHYLHISTIDINES/URINE; NITROGEN/METABOLISM; SUPPORT, U.S. GOV'T, P.H.S; VALINE/ADMINISTRATION & DOSAGE; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER; CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL
Availability Source: Other Sources
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