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Attenuation of the protein wasting associated with bed rest by branched-chain amino acidsBed rest is generally accepted as being an appropriate ground-based model for human spaceflight. The objectives of this study were to test the hypothesis that increasing the amount of branched-chain amino acids (BCAAs) in the diet could attenuate the protein loss associated with bed rest. Nineteen healthy subjects were randomized into two groups according to diet. During the 6 d of bed rest, the diets were supplemented with either 30 mmol/d each of three non-essential amino acids, glycine, serine, and alanine (control group), or with 30 mmol/d each of the BCAAs, leucine, isoleucine, and valine (BCAA group). Nutrition was supplied as a commercially available defined formula diet at a rate of 1.3 x REE. Nitrogen (N) balance and urinary 3-MeH excretion were determined for the 6 d. In our results, the urine-based estimate of N balance was 22.2 +/- 14.4 (n = 9) mg N.kg-1.d-1 and 60.5 +/- 10.1 mg (n = 8) N.kg-1.d-1 for the control and BCAA-supplemented groups, respectively (P < 0.05). Urinary 3-MeH excretion was unchanged in both groups with bed rest. We conclude that BCAA supplementation attenuates the N loss during short-term bed rest.
Document ID
20040141847
Document Type
Reprint (Version printed in journal)
Authors
Stein, T. P. (University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine Stratford 08084, United States)
Schluter, M. D.
Leskiw, M. J.
Boden, G.
Date Acquired
August 22, 2013
Publication Date
September 1, 1999
Publication Information
Publication: Nutrition (Burbank, Los Angeles County, Calif.)
Volume: 15
Issue: 9
ISSN: 0899-9007
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: RO1 AG14078
CONTRACT_GRANT: R01 AA 10221
CONTRACT_GRANT: RO1 AG 07988
Distribution Limits
Public
Copyright
Other
Keywords
Randomized Controlled Trial
Non-NASA Center
NASA Discipline Musculoskeletal
Clinical Trial