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Applications of amorphous track models in radiation biologyThe average or amorphous track model uses the response of a system to gamma-rays and the radial distribution of dose about an ion's path to describe survival and other cellular endpoints from proton, heavy ion, and neutron irradiation. This model has been used for over 30 years to successfully fit many radiobiology data sets. We review several extensions of this approach that address objections to the original model, and consider applications of interest in radiobiology and space radiation risk assessment. In the light of present views of important cellular targets, the role of target size as manifested through the relative contributions from ion-kill (intra-track) and gamma-kill (inter-track) remains a critical question in understanding the success of the amorphous track model. Several variations of the amorphous model are discussed, including ones that consider the radial distribution of event-sizes rather than average electron dose, damage clusters rather than multiple targets, and a role for repair or damage processing.
Document ID
20040141852
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Cucinotta, F. A.
(NASA Johnson Space Center Houston TX United States)
Nikjoo, H.
Goodhead, D. T.
Wilson, J. W.
Date Acquired
August 22, 2013
Publication Date
July 1, 1999
Publication Information
Publication: Radiation and environmental biophysics
Volume: 38
Issue: 2
ISSN: 0301-634X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Review
Review, Tutorial

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