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Distribution and time course of hair cell regeneration in the pigeon utricleVestibular and cochlear regeneration following ototoxic insult from aminoglycoside antibiotics has been well documented, particularly in birds. In the present study, intraotic application of a 2 mg streptomycin paste was used to achieve complete vestibular hair cell destruction in pigeons (Columba livia) while preserving regenerative ability. Scanning electron microscopy was used to quantify hair cell density longitudinally during regeneration in three different utricular macula locations, including the striola, central and peripheral regions. The utricular epithelium was void of stereocilia (indicating hair cell loss) at 4 days after intraotic treatment with streptomycin. At 2 weeks the stereocilia began to appear randomly and mostly in an immature form. However, when present most kinocilia were polarized toward the developing striola. Initially, regeneration occurred more rapidly in the central and peripheral regions of the utricle as compared to the striola. As regeneration proceeded from 2 to 12 weeks, hair cell density in the striola region equaled the density noted in the central and peripheral regions. At 24 weeks, hair cell density of the central and peripheral regions was equal to normal values, however the striola region had a slightly greater hair cell density than that observed for normal animals.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Dye, B. J.
(University of Mississippi Medical Center, Department of Surgery Jackson 39216-4505, United States)
Frank, T. C.
Newlands, S. D.
Dickman, J. D.
Date Acquired
August 22, 2013
Publication Date
July 1, 1999
Publication Information
Publication: Hearing research
Volume: 133
Issue: 2-Jan
ISSN: 0378-5955
Subject Category
Life Sciences (General)
Funding Number(s)
Distribution Limits
Non-NASA Center
NASA Discipline Neuroscience

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