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Record 30 of 210
Stability, precision, and near-24-hour period of the human circadian pacemaker
External Online Source: doi:10.1126/science.284.5423.2177
Author and Affiliation:
Czeisler, C. A.(Harvard Medical School, Brigham and Women's Hospital, Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, 221 Longwood Avenue, Boston, MA 02115, United States)
Duffy, J. F.
Shanahan, T. L.
Brown, E. N.
Mitchell, J. F.
Rimmer, D. W.
Ronda, J. M.
Silva, E. J.
Allan, J. S.
Emens, J. S. Show more authors
Abstract: Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to light levels sufficient to confound circadian period estimation. Precise estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals living in carefully controlled lighting conditions has now revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species. These findings have important implications for understanding the pathophysiology of disrupted sleep in older people.
Publication Date: Jun 25, 1999
Document ID:
20040141918
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Science (ISSN 0036-8075); Volume 284; 5423; 2177-81
Publisher Information: United States
Contract/Grant/Task Num: MO1-RR02635; PO1-AG09975; R01-GM53559
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AGING; CIRCADIAN RHYTHMS; RHYTHM (BIOLOGY); STABILITY; ADULTS; AGE FACTOR; BODY TEMPERATURE; DARKNESS; FEMALES; GENETICS; HYDROXYCORTICOSTEROID; LIGHT (VISIBLE RADIATION); MALES; MELATONIN; SLEEP
Other Descriptors: AGING/PHYSIOLOGY; BIOLOGICAL CLOCKS/GENETICS/PHYSIOLOGY; CIRCADIAN RHYTHM/GENETICS/PHYSIOLOGY; ADULT; AGED; BODY TEMPERATURE; COMPARATIVE STUDY; DARKNESS; FEMALE; HUMAN; HYDROCORTISONE/BLOOD; LIGHT; MALE; MELATONIN/BLOOD; MIDDLE AGED; SLEEP; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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