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Effect of furosemide on pulmonary blood flow distribution in resting and exercising horsesWe determined the spatial distribution of pulmonary blood flow (PBF) with 15-micron fluorescent-labeled microspheres during rest and exercise in five Thoroughbred horses before and 4 h after furosemide administration (0.5 mg/kg iv). The primary finding of this study was that PBF redistribution occurred from rest to exercise, both with and without furosemide. However, there was less blood flow to the dorsal portion of the lung during exercise postfurosemide compared with prefurosemide. Furosemide did alter the resting perfusion distribution by increasing the flow to the ventral regions of the lung; however, that increase in flow was abated with exercise. Other findings included 1) unchanged gas exchange and cardiac output during rest and exercise after vs. before furosemide, 2) a decrease in pulmonary arterial pressure after furosemide, 3) an increase in the slope of the relationship of PBF vs. vertical height up the lung during exercise, both with and without furosemide, and 4) a decrease in blood flow to the dorsal region of the lung at rest after furosemide. Pulmonary perfusion variability within the lung may be a function of the anatomy of the pulmonary vessels that results in a predominantly fixed spatial pattern of flow distribution.
Document ID
20040141929
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Erickson, H. H.
(Kansas State University Manhattan, Kansas 66506-5602, United States)
Bernard, S. L.
Glenny, R. W.
Fedde, M. R.
Polissar, N. L.
Basaraba, R. J.
Walther, S. M.
Gaughan, E. M.
McMurphy, R.
Hlastala, M. P.
Date Acquired
August 22, 2013
Publication Date
June 1, 1999
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 86
Issue: 6
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL-24163
CONTRACT_GRANT: HL-12174
CONTRACT_GRANT: HL-02625
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

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