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Role of the anterior region of the third ventricle in the cardiovascular responses produced by systemic injection of a nitric oxide synthase inhibitorThis study examined whether a prior electrolytic lesion of the tissue surrounding the anteroventral third ventricle (AV3V) would affect the increase in mean arterial blood pressure (MAP) and the fall in heart rate (HR) produced by systemic injection of the nitric oxide synthesis (NOS) inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 25 micromol/kg, i.v.) in conscious rats. L-NAME produced a smaller increase in MAP in AV3V-lesion than in sham-lesion rats (+19+/-3 vs. +40+/-3 mmHg, respectively; P<0.05). In contrast, L-NAME produced similar falls in HR in the AV3V-lesion and sham-lesion rats (-103+/-15 vs. -97+/-8 bpm, respectively; P<0.05). These findings demonstrate that the L-NAME-induced pressor response is dependent upon the integrity of the AV3V region, whereas the L-NAME-induced bradycardia is not. Copyright 1999 Elsevier Science B. V.
Document ID
20040141943
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Lewis, S. J.
(University of Iowa Iowa City, IA, 52242-1407, United States)
Whalen, E. J.
Beltz, T. G.
Johnson, A. K.
Date Acquired
August 22, 2013
Publication Date
May 29, 1999
Publication Information
Publication: Brain research
Volume: 830
Issue: 1
ISSN: 0006-8993
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL 14388
CONTRACT_GRANT: HL57472
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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