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Record 40 of 3039
Effects of immersion in cool water on lung-exhaled nitric oxide at rest and during exercise
External Online Source: doi:10.1016/S0034-5687(99)00006-7
Author and Affiliation:
Pendergast, D. R.(University at Buffalo, School of Medicine and Biomedical Sciences, Department of Physiology, NY 14214, United States)
Krasney, J. A.
DeRoberts, D.
Farhi, L. E. [Principal Investigator]
Abstract: Lung nitric oxide (NO) has been postulated to relax airway and vascular smooth muscle at rest and during exercise. As a cold environment is a common cause of respiratory distress, lung exhaled NO was measured during skin and core body cooling at rest and during a progressive cycle exercise. Ten healthy male subjects were immersed in water at a water temperature (Tw) which was thermal neutral (35 degrees C) at 30 degrees C Tw, at which only skin temperature is decreased; and at 20 degrees C Tw, at which the core temperature is decreased (0.05 degrees C). At rest, V(O), and V(E) increased while exhaled NO concentration [NO] and the rate of expiration of NO (V(NO)) decreased with decreased Tw. V(O2) and ventilation (V(E)) increased with workload (W) and the values at all Tw were not different, whereas, [NO] decreased with W and the values during exercise were progressively less at all Ws as Tw declined. These results indicate that lung NO output is reduced in a graded fashion during body cooling at rest and during exercise. This suggests that lower lung NO may contribute to airway obstruction in cold environments and NO may contribute to regulation of lung heat and water exchange.
Publication Date: Jan 01, 1999
Document ID:
20040141947
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Respiration physiology (ISSN 0034-5687); Volume 115; 1; 73-81
Publisher Information: Netherlands
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: LOW TEMPERATURE; LUNGS; NITRIC OXIDE; PHYSICAL EXERCISE; RESPIRATION; SUBMERGING; WATER IMMERSION; ADULTS; BODY TEMPERATURE; MALES; REST; SKIN TEMPERATURE (BIOLOGY)
Other Descriptors: COLD; IMMERSION; NITRIC OXIDE; RESPIRATION; ADULT; BODY TEMPERATURE/PHYSIOLOGY; EXERCISE/PHYSIOLOGY; HUMAN; MALE; REST; SKIN TEMPERATURE/PHYSIOLOGY; SUPPORT, U.S. GOV'T, NON-P.H.S; NASA DISCIPLINE CARDIOPULMONARY; NON-NASA CENTER
Availability Source: Other Sources
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