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Effects of immersion in cool water on lung-exhaled nitric oxide at rest and during exerciseLung nitric oxide (NO) has been postulated to relax airway and vascular smooth muscle at rest and during exercise. As a cold environment is a common cause of respiratory distress, lung exhaled NO was measured during skin and core body cooling at rest and during a progressive cycle exercise. Ten healthy male subjects were immersed in water at a water temperature (Tw) which was thermal neutral (35 degrees C) at 30 degrees C Tw, at which only skin temperature is decreased; and at 20 degrees C Tw, at which the core temperature is decreased (0.05 degrees C). At rest, V(O), and V(E) increased while exhaled NO concentration [NO] and the rate of expiration of NO (V(NO)) decreased with decreased Tw. V(O2) and ventilation (V(E)) increased with workload (W) and the values at all Tw were not different, whereas, [NO] decreased with W and the values during exercise were progressively less at all Ws as Tw declined. These results indicate that lung NO output is reduced in a graded fashion during body cooling at rest and during exercise. This suggests that lower lung NO may contribute to airway obstruction in cold environments and NO may contribute to regulation of lung heat and water exchange.
Document ID
20040141947
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Pendergast, D. R.
(University at Buffalo, School of Medicine and Biomedical Sciences NY 14214, United States)
Krasney, J. A.
DeRoberts, D.
Farhi, L. E.
Date Acquired
August 22, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Respiration physiology
Volume: 115
Issue: 1
ISSN: 0034-5687
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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