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Record Details

Record 2 of 1427
T2 vertebral bone marrow changes after space flight
External Online Source: doi:10.1002/(SICI)1522-2594(199903)41:3<495::AID-MRM11>3.0.CO;2-V
Author and Affiliation:
LeBlanc, A.(Baylor College of Medicine, Department of Medicine, Houston, Texas, United States)
Lin, C.
Evans, H.
Shackelford, L.
Martin, C.
Hedrick, T.
Abstract: Bone biopsies indicate that during immobilization bone marrow adipose tissue increases while the functional cellular fraction decreases. One objective of our Spacelab flight experiment was to determine, using in vivo volume-localized magnetic resonance spectroscopy (VLMRS), whether bone marrow composition was altered by space flight. Four crew members of a 17 day Spacelab mission participated in the experiment. The apparent cellular fraction and transverse relaxation time (T2) were determined twice before launch and at several times after flight. Immediately after flight, no significant change in the cellular fraction was found. However, the T2 of the cellular, but not the fat component increased following flight, although to a variable extent, in all crew members with a time course for return to baseline lasting several months. The T2 of seven control subjects showed no significant change. Although these observations may have several explanations, it is speculated that the observed T2 changes might reflect increased marrow osteoblastic activity during recovery from space flight.
Publication Date: Mar 01, 1999
Document ID:
20040141994
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (ISSN 0740-3194); Volume 41; 3; 495-8
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BONE MARROW; IMAGING TECHNIQUES; LUMBAR REGION; MAGNETIC RESONANCE; VERTEBRAE; ADULTS; MALES; SPACE SHUTTLE MISSIONS
Other Descriptors: BONE MARROW/PATHOLOGY; LUMBAR VERTEBRAE/PATHOLOGY; MAGNETIC RESONANCE IMAGING/METHODS; SPACE FLIGHT; ADULT; BIOPSY, NEEDLE; HUMAN; MALE; MIDDLE AGED; REFERENCE VALUES; SUPPORT, U.S. GOV'T, NON-P.H.S; NASA DISCIPLINE MUSCULOSKELETAL; NASA EXPERIMENT NUMBER 284054; NON-NASA CENTER; FLIGHT EXPERIMENT; STS-78 SHUTTLE PROJECT; MANNED; SHORT DURATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL
Availability Source: Other Sources
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