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Leukocyte subsets and neutrophil function after short-term spaceflightChanges in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil function. At landing, a 1.5-fold increase in neutrophils was observed compared with preflight values; lymphocytes were slightly decreased, whereas the results were variable for monocytes. No significant changes were observed in plasma levels of immunoglobulins, cortisol, or adrenocorticotropic hormone. In contrast, urinary epinephrine, norepinephrine, and cortisol were significantly elevated at landing. Band neutrophils were observed in 9 of 16 astronauts. Neutrophil chemotactic assays showed a 10-fold decrease in the optimal dose response after landing. Neutrophil adhesion to endothelial cells was increased both before and after spaceflight. At landing, the expression of MAC-1 was significantly decreased while L-selectin was significantly increased. These functional alterations may be of clinical significance on long-duration space missions.
Document ID
20040142033
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Stowe, R. P.
(University of Texas Medical Branch Galveston, United States)
Sams, C. F.
Mehta, S. K.
Kaur, I.
Jones, M. L.
Feeback, D. L.
Pierson, D. L.
Date Acquired
August 22, 2013
Publication Date
February 1, 1999
Publication Information
Publication: Journal of leukocyte biology
Volume: 65
Issue: 2
ISSN: 0741-5400
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
short duration
Flight Experiment
STS Shuttle Project
manned
NASA Center JSC
NASA Discipline Regulatory Physiology

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