NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon
 

Record Details

Record 1 of 420
System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy
Author and Affiliation:
Mukkamala, R.(Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge Massachusetts 02139, United States)
Mathias, J. M.
Mullen, T. J.
Cohen, R. J.
Freeman, R.
Abstract: We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patients with diabetic autonomic neuropathy (DAN). The CSI method quantitatively analyzes beat-to-beat fluctuations in noninvasively measured heart rate, arterial blood pressure (ABP), and instantaneous lung volume (ILV) to characterize four physiological coupling mechanisms, two of which are autonomically mediated (the heart rate baroreflex and the coupling of respiration, measured in terms of ILV, to heart rate) and two of which are mechanically mediated (the coupling of ventricular contraction to the generation of the ABP wavelet and the coupling of respiration to ABP). We studied 37 control and 60 diabetic subjects who were classified as having minimal, moderate, or severe DAN on the basis of standard autonomic tests. The autonomically mediated couplings progressively decreased with increasing severity of DAN, whereas the mechanically mediated couplings were essentially unchanged. CSI identified differences between the minimal DAN and control groups, which were indistinguishable based on the standard autonomic tests. CSI may provide a powerful tool for assessing DAN.
Publication Date: Mar 01, 1999
Document ID:
20040142041
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: The American journal of physiology; p. R905-12; (ISSN 0002-9513); Volume 276; 3 Pt 2
Publisher Information: United States
Contract/Grant/Task Num: 5-R01-HL39291
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR SYSTEM; DIABETES MELLITUS; DISEASES; FEEDBACK CONTROL; METABOLIC DISEASES; SYSTEM IDENTIFICATION; ADULTS; AGE FACTOR; BLOOD PRESSURE; HEART RATE; LUNGS; MODELS; PHYSIOLOGICAL RESPONSES; POSTURE; RESPIRATION; TILT-TABLE TEST
Other Descriptors: AUTONOMIC NERVOUS SYSTEM DISEASES/PHYSIOPATHOLOGY; CARDIOVASCULAR SYSTEM/PHYSIOPATHOLOGY; DIABETIC NEUROPATHIES/PHYSIOPATHOLOGY; ADULT; AGED; BLOOD PRESSURE/PHYSIOLOGY; HEART RATE/PHYSIOLOGY; HUMAN; LUNG VOLUME MEASUREMENTS; MODELS, CARDIOVASCULAR; POSTURE/PHYSIOLOGY; RESPIRATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; TILT-TABLE TEST; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
› Back to Top
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: August 23, 2011
Contact Us