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ARG1 (altered response to gravity) encodes a DnaJ-like protein that potentially interacts with the cytoskeletonGravitropism allows plant organs to direct their growth at a specific angle from the gravity vector, promoting upward growth for shoots and downward growth for roots. Little is known about the mechanisms underlying gravitropic signal transduction. We found that mutations in the ARG1 locus of Arabidopsis thaliana alter root and hypocotyl gravitropism without affecting phototropism, root growth responses to phytohormones or inhibitors of auxin transport, or starch accumulation. The positional cloning of ARG1 revealed a DnaJ-like protein containing a coiled-coil region homologous to coiled coils found in cytoskeleton-interacting proteins. These data suggest that ARG1 participates in a gravity-signaling process involving the cytoskeleton. A combination of Northern blot studies and analysis of ARG1-GUS fusion-reporter expression in transgenic plants demonstrated that ARG1 is expressed in all organs. Ubiquitous ARG1 expression in Arabidopsis and the identification of an ortholog in Caenorhabditis elegans suggest that ARG1 is involved in other essential processes.
Document ID
Document Type
Reprint (Version printed in journal)
External Source(s)
Sedbrook, J. C.
(University of Wisconsin-Madison 445 Henry Mall, Madison, WI 53706, United States)
Chen, R.
Masson, P. H.
Date Acquired
August 22, 2013
Publication Date
February 2, 1999
Publication Information
Publication: Proceedings of the National Academy of Sciences of the United States of America
Volume: 96
Issue: 3
ISSN: 0027-8424
Subject Category
Life Sciences (General)
Funding Number(s)
Distribution Limits
Non-NASA Center
NASA Discipline Plant Biology

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