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Radiation-induced instability and its relation to radiation carcinogenesisPURPOSE: A model that identifies radiation-induced genetic instability as the earliest cellular event in the multi-step sequence leading to radiation-induced cancer was previously proposed. In this paper ongoing experiments are discussed which are designed to test this model and its predictions in mouse mammary epithelial cells. RESULTS: Several lines of evidence are presented that appear to support this model: first, the development of delayed mutations in p53 following irradiation in altered growth variants; secondly, the high frequencies for the induction of both instability and transformation following irradiation in mammary epithelial cells; and finally, the demonstration that susceptibility to the induction of cytogenetic instability is a heritable trait that correlates with susceptibility to transformation and radiation-induced mammary cancer. Mice resistant to transformation and mammary cancer development are also resistant to the development of instability after irradiation. In contrast, mice sensitive to transformation and cancer are also sensitive to the development of cytogenetic instability. CONCLUSIONS: Data from this laboratory and from the studies cited above suggest a specific, and perhaps unique, role for radiation-induced instability as a critical early event associated with initiation of the carcinogenic process.
Document ID
20040142118
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Ullrich, R. L.
(The University of Texas Medical Branch, Department of Radiation Oncology Galveston 77555-0656, United States)
Ponnaiya, B.
Date Acquired
August 22, 2013
Publication Date
December 1, 1998
Publication Information
Publication: International journal of radiation biology
Volume: 74
Issue: 6
ISSN: 0955-3002
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA43322
CONTRACT_GRANT: CA73929
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
NASA Discipline Radiation Health
Review, Tutorial

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