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Albumin infusion in humans does not model exercise induced hypervolaemia after 24 hoursWe rapidly infused 234 +/- 3 mL of 5% human serum albumin in eight men while measuring haematocrit, haemoglobin concentration, plasma volume (PV), albumin concentration, total protein concentration, osmolality, sodium concentration, renin activity, aldosterone concentration, and atrial natriuretic peptide concentration to test the hypotheses that plasma volume expansion and plasma albumin content expansion will not persist for 24 h. Plasma volume and albumin content were expanded for the first 6 h after infusion (44.3 +/- 1.9-47.2 +/- 2.0 mL kg-1 and 1.9 +/- 0.1-2.1 +/- 0.1 g kg-1 at pre-infusion and 1 h, respectively, P < 0.05), but by 24 h plasma volume and albumin content decreased significantly from 1 h post-infusion and were not different from pre-infusion (44.8 +/- 1.9 mL kg-1 and 1.9 +/- 0.1 g kg-1, respectively). Plasma aldosterone concentration showed a significant effect of time over the 24 h after infusion (P < 0.05), and showed a trend to decrease at 2 h after infusion (167.6 +/- 32.5(-1) 06.2 +/- 13.4 pg mL-1, P = 0.07). These data demonstrate that a 6.8% expansion of plasma volume and 10.5% expansion of plasma albumin content by infusion does not remain in the vascular space for 24 h and suggest a redistribution occurs between the intravascular space and interstitial fluid space.
Document ID
20040142138
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Haskell, A.
(John B. Pierce Laboratory New Haven, CT 06519, United States)
Gillen, C. M.
Mack, G. W.
Nadel, E. R.
Date Acquired
August 22, 2013
Publication Date
November 1, 1998
Publication Information
Publication: Acta physiologica Scandinavica
Volume: 164
Issue: 3
ISSN: 0001-6772
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL39818
CONTRACT_GRANT: HL 20634
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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