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Record Details

Record 6 of 1841
Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas
External Online Source: doi:10.1002/(SICI)1097-4598(199812)21:12<1748::AID-MUS18>3.0.CO;2-K
Author and Affiliation:
Macias, M. Y.(Medical College of Wisconsin, Department of Cell Biology, Neurobiology, and Anatomy, Milwaukee 53226, United States)
Lehman, C. T.
Sanger, J. R.
Riley, D. A.
Abstract: Histochemical staining for carbonic anhydrase and cholinesterase (CE) activities was used to analyze sensory and motor axon regeneration, respectively, during neuroma formation in transected and tube-encapsulated peripheral nerves. Median-ulnar and sciatic nerves in the rodent model permitted testing whether a 4 cm greater distance of the motor neuron soma from axotomy site or intrinsic differences between motor and sensory neurons influenced regeneration and neuroma formation 10, 30, and 90 days later. Ventral root radiculotomy confirmed that CE-stained axons were 97% alpha motor axons. Distance significantly delayed axon regeneration. When distance was negligible, sensory axons grew out sooner than motor axons, but motor axons regenerated to a greater quantity. These results indicate regeneration differences between axon subtypes and suggest more extensive branching of motor axons within the neuroma. Thus, both distance from injury site to soma and inherent motor and sensory differences should be considered in peripheral nerve repair strategies.
Publication Date: Dec 01, 1998
Document ID:
20040142150
(Acquired Nov 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Muscle & nerve (ISSN 0148-639X); Volume 21; 12; 1748-58
Publisher Information: United States
Contract/Grant/Task Num: UOLNS33472-01
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AFFERENT NERVOUS SYSTEMS; AXONS; EFFERENT NERVOUS SYSTEMS; NEOPLASMS; NERVE FIBERS; NERVES; NEURONS; PERIPHERAL NERVOUS SYSTEM; CARBONIC ANHYDRASE; CHOLINESTERASE; MALES; PATHOLOGY; RATS
Other Descriptors: AXONS/PHYSIOLOGY; MOTOR NEURONS/PHYSIOLOGY; NERVE FIBERS, MYELINATED/PHYSIOLOGY; NERVE REGENERATION/PHYSIOLOGY; NEUROMA/PATHOLOGY/PHYSIOPATHOLOGY; NEURONS, AFFERENT/PHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM NEOPLASMS/PATHOLOGY/PHYSIOPATHOLOGY; ANIMALS; CARBONIC ANHYDRASES/METABOLISM; CHOLINESTERASES/METABOLISM; MALE; PERIPHERAL NERVES/ENZYMOLOGY; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER
Availability Source: Other Sources
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