NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectivenessShortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.
Document ID
20040142178
Document Type
Reprint (Version printed in journal)
Authors
Blakely, E. A. (Ernest Orlando Lawrence Berkeley National Laboratory Berkeley, California 94720, United States)
Kronenberg, A.
Chatterjee, A.
Date Acquired
August 22, 2013
Publication Date
November 1, 1998
Publication Information
Publication: Radiation research
Volume: 150
Issue: 5 Suppl
ISSN: 0033-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: EY10737
CONTRACT_GRANT: CA73966
Distribution Limits
Public
Copyright
Other
Keywords
Review, Academic
Non-NASA Center
Review
NASA Discipline Radiation Health