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How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissuesThe capacity of ionizing radiation to affect tissue function, control tumor growth and elicit pathological sequelae has been attributed in great part to its effects on cellular DNA, which, as the transmitter of genetic information, can both register damage and perpetuate it. Nonetheless, multicellular organisms function as the result of the cooperation of many cell types. What then occurs when individual cells are damaged by ionizing radiation? Is tissue response a sum of cellular effects such as cell death and DNA damage? Or does the tissue respond as a coherent unit to the damage of its parts? In this paper, data in support of the latter model that indicate a role for cytokines, in particular transforming growth factor beta1, as critical components of extracellular signaling pathways that mediate tissue response to radiation will be reviewed. The key to manipulating the consequences of radiation exposure lies in understanding the complex interplay of events initiated at the cellular level, but acting on the tissue.
Document ID
20040142179
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Barcellos-Hoff, M. H.
(Lawrence Berkeley National Laboratory, University of California Berkeley 94720, United States)
Chatterjee, A.
Date Acquired
August 22, 2013
Publication Date
November 1, 1998
Publication Information
Publication: Radiation research
Volume: 150
Issue: 5 Suppl
ISSN: 0033-7587
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial
Non-NASA Center
NASA Discipline Radiation Health

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