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Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapyThe primary objective of this study was to evaluate the antitumor effects of recombinant vaccinia virus-p53 (rVV-p53) in combination with radiation therapy against the C6 rat glioma, a p53 deficient tumor that is relatively radioresistant. VV-LIVP, the parental virus (Lister strain), was used as a control. Localized treatment of subcutaneous C6 tumors in athymic mice with either rVV-p53 or VV-LIVP together with tumor irradiation resulted in low tumor incidence and significantly slower tumor progression compared to the agents given as single modalities. Assays of blood and spleen indicated that immune system activation may account, at least partly, for the enhance tumor inhibition seen with combined treatment. No overt signs of treatment-related toxicity were noted.
Document ID
20040142211
Document Type
Reprint (Version printed in journal)
Authors
Gridley, D. S. (Cancer Research Institute, Loma Linda University School of Medicine Room A-1010, Loma Linda, CA 92354, United States)
Andres, M. L.
Li, J.
Timiryasova, T.
Chen, B.
Fodor, I.
Nelson, G. A.
Date Acquired
August 22, 2013
Publication Date
November 1, 1998
Publication Information
Publication: International journal of oncology
Volume: 13
Issue: 5
ISSN: 1019-6439
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Non-NASA Center