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High Salt Intake Promotes Urinary Loss of Vitamin D Metabolites by Dahl Salt-Sensitive Rats in a Space Flight ModelVitamin D metabolism in the Dahl salt-sensitive (S) rat, a model of salt-induced hypertension, differs from that in the Dahl salt-resistant (R) rat. We have demonstrated that female S rats are more vulnerable than female R rats to decreases in plasma 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentrations during hind limb unloading (a space flight model). We report here on the response of the vitamin D endocrine system of S and R rats to hind limb unloading during high salt intake. Dahl female rats (9.7-week-old) were tail-suspended (hind limb unloaded) for 28 days, while fed a diet containing twice the salt in standard rat chow (2 % sodium chloride). Control rats were fed the same diet, but were not hind limb unloaded. Vitamin D metabolites were analyzed by HPLC and radioimmunoassay kits from Diasorin.
Document ID
20040161128
Document Type
Preprint (Draft being sent to journal)
Authors
Thierry-Palmer, M. (Morehouse School of Medicine Atlanta, GA, United States)
Cephas, S. (Morehouse School of Medicine Atlanta, GA, United States)
Sayavongsa, P. (NASA Ames Research Center Moffett Field, CA, United States)
Clark, T. (NASA Ames Research Center Moffett Field, CA, United States)
Arnaud, S. B. (NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 22, 2013
Publication Date
May 5, 2004
Subject Category
Life Sciences (General)
Report/Patent Number
Rept-04-A-179-ASBMR
Meeting Information
American Society for Bone and Mineral Research 26th Annual Meeting(Seattle, WA)
Funding Number(s)
CONTRACT_GRANT: NCC9-112
CONTRACT_GRANT: NAG2-1381
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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