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Role of digitalis-like substance in the hypertension of streptozotocin-induced diabetes and simulated weightlessness in ratsWe have examined the role of plasma Na+-K+ pump inhibitor (SPI) in the hypertension of streptozotocin induced insulin dependent diabetes (IDDM) in reduced renal mass rats. The increase in blood pressure (BP) was associated with an increase in extracellular fluid volume (ECFV), and SPI and a decrease in myocardial Na+,K+ATPase (NKA) activity, suggesting that increased SPI, which inhibits cardiovascular muscle (CVM) cell NKA activity, may be involved in the mechanism of IDDM-hypertension. In a second study, using prolonged suspension resulted in a decrease in cardiac NKA activity, suggesting that cardiovascular deconditioning following space flight might in part result from insufficient SPI.
Document ID
Document Type
Reprint (Version printed in journal)
Pamnani, M. B. (Uniformed Services University of the Health Sciences Bethesda, MD 20814, United States)
Chen, S.
Haddy, F. J.
Yuan, C.
Mo, Z.
Date Acquired
August 22, 2013
Publication Date
July 1, 1998
Publication Information
Publication: Clinical and experimental hypertension (New York, N.Y. : 1993)
Volume: 20
Issue: 5-6
ISSN: 1064-1963
Subject Category
Aerospace Medicine
Distribution Limits
NASA Discipline Regulatory Physiology
Non-NASA Center