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Mutagenicity of arsenic in mammalian cells: role of reactive oxygen speciesArsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (AL cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations. Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide significantly reduces the mutagenicity of arsenite. Thus, the carcinogenicity of arsenite can be explained at least in part by it being a mutagen that depends on reactive oxygen species for its activity.
Document ID
20040172639
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Hei, T. K.
(College of Physicians and Surgeons, School of Public Health, Columbia University New York, NY 10032, United States)
Liu, S. X.
Waldren, C.
Date Acquired
August 22, 2013
Publication Date
July 7, 1998
Publication Information
Publication: Proceedings of the National Academy of Sciences of the United States of America
Volume: 95
Issue: 14
ISSN: 0027-8424
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA 49062
CONTRACT_GRANT: CA 36447
CONTRACT_GRANT: ES 08821
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Radiation Health

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