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Resetting of circadian melatonin and cortisol rhythms in humans by ordinary room lightThe present study was designed to investigate whether a weak photic stimulus can reset the endogenous circadian rhythms of plasma melatonin and plasma cortisol in human subjects. A stimulus consisting of three cycles of 5 h exposures to ordinary room light (approximately 180 lux), centered 1.5 h after the endogenous temperature nadir, significantly phase-advanced the plasma melatonin rhythm in eight healthy young men compared with the phase delays observed in eight control subjects who underwent the same protocol but were exposed to darkness (p < or = 0.003). After light-induced phase advances, the circadian rhythms of plasma melatonin and plasma cortisol maintained stable temporal relationships with the endogenous core body temperature cycle, consistent with the conclusion that exposure to ordinary indoor room light had shifted a master circadian pacemaker.
Document ID
20040172703
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Boivin, D. B.
(Brigham and Women's Hospital, Harvard Medical School Boston, MA 02115, United States)
Czeisler, C. A.
Date Acquired
August 22, 2013
Publication Date
March 30, 1998
Publication Information
Publication: Neuroreport
Volume: 9
Issue: 5
ISSN: 0959-4965
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NIMH-1-R01-MH45130
CONTRACT_GRANT: GCRC-2-M01-RR02635
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology
Clinical Trial

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