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Cellular control lies in the balance of forcesMechanical tension generated within the cytoskeleton of living cells is emerging as a critical regulator of biological function in diverse situations ranging from the control of chromosome movement to the morphogenesis of the vertebrate brain. In this article, we review recent advances that have been made in terms of understanding how cells generate, transmit and sense mechanical tension, as well as how they use these forces to control their shape and behavior. An integrated view of cell regulation that incorporates mechanics and structure as well as chemistry is beginning to emerge.
Document ID
20040172722
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Chicurel, M. E.
(Children's Hospital Boston, MA, United States)
Chen, C. S.
Ingber, D. E.
Date Acquired
August 22, 2013
Publication Date
April 1, 1998
Publication Information
Publication: Current opinion in cell biology
Volume: 10
Issue: 2
ISSN: 0955-0674
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
NASA Discipline Cell Biology
Review
Non-NASA Center

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