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Record 21 of 6268
Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans
External Online Source: doi:10.1023/A:1011962501270
Author and Affiliation:
Rhie, J. K.(University of Michigan, College of Pharmacy, Ann Arbor, United States)
Hayashi, Y.
Welage, L. S.
Frens, J.
Wald, R. J.
Barnett, J. L.
Amidon, G. E.
Putcha, L.
Amidon, G. L.
Abstract: PURPOSE: The objective of this study was to evaluate drug marker absorption in relation to the gastric emptying (GE) of 0.7 mm and 3.6 mm enteric coated pellets as a function of viscosity and the underlying gastric motility. METHODS: Twelve subjects were evaluated in a 3-way crossover study. 0.7 mm caffeine and 3.6 mm acetaminophen enteric coated pellets were concurrently administered with a viscous caloric meal at the levels of 4000, 6000 and 8000 cP. Gastric motility was simultaneously measured with antral manometry and compared to time events in the plasma profiles of the drug markers. RESULTS: Caffeine, from the 0.7 mm pellets, was observed significantly earlier in the plasma than acetaminophen, from the 3.6 mm pellets, at all levels of viscosity. Motility related size differentiated GE was consistently observed at all viscosity levels, however, less variability was observed with the 4000 cP meal. Specifically, the onset of absorption from the of 3.6 mm pellets correlated with the onset of Phase II fasted state contractions (r = 0.929, p < 0.01). CONCLUSIONS: The timeframe of drug marker absorption and the onset of motility events were not altered within the range of viscosities evaluated. Rather, the differences in drug marker profiles from the non-digestible solids were most likely the result of the interaction between viscosity and motility influencing antral flow dynamics. The administration of the two sizes of pellets and a viscous caloric meal with subsequent monitoring of drug marker profiles is useful as a reference to assess the influence of motility patterns on the absorption profile of orally administered agents.
Publication Date: Feb 01, 1998
Document ID:
20040172747
(Acquired Dec 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Pharmaceutical research (ISSN 0724-8741); Volume 15; 2; 233-8
Publisher Information: United States
Contract/Grant/Task Num: M01 RR00042
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CAFFEINE; DRUGS; LOCOMOTION; MARKERS; PELLETS; STOMACH; ADULTS; FEMALES; MALES; STATISTICAL ANALYSIS; VISCOSITY
Other Descriptors: ACETAMINOPHEN/PHARMACOKINETICS; CAFFEINE/PHARMACOKINETICS; FOOD-DRUG INTERACTIONS; GASTRIC EMPTYING; ADULT; AREA UNDER CURVE; FEMALE; HUMAN; MALE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; VISCOSITY; NASA CENTER JSC; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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