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Record Details

Record 88 of 1076
Relation of blood volume and blood pressure in orthostatic intolerance
External Online Source: doi:10.1097/00000441-199802000-00005
Author and Affiliation:
Jacob, G.(Clinical Research Center, Vanderbilt University, Department of Medicine, Nashville, Tennessee 37232-2195, United States)
Biaggioni, I.
Mosqueda-Garcia, R.
Robertson, R. M.
Robertson, D.
Abstract: A complex but crucial relationship exists between blood volume and blood pressure in human subjects; it has been recognized that in essential hypertension, renovascular hypertension, and pheochromocytoma, the relationship between plasma volume and diastolic blood pressure is an inverse one. This phenomenon has not been studied in individuals with low normal and reduced blood pressures. Orthostatic intolerance is a commonly encountered abnormality in blood pressure regulation often associated with tachycardia in the standing position. Most of these patients have varying degrees of reduced blood volume. We tested the hypothesis that the relationship previously found between plasma volume and diastolic blood pressure in pressor states would also hold in orthostatic intolerance. We studied 16 patients with a history of symptomatic orthostatic intolerance associated with an elevation in plasma norepinephrine in the upright posture and hypovolemia in 9 patients and normovolemia in 7 patients. Our studies demonstrate an inverse relationship between plasma volume and diastolic blood pressure in patients with orthostatic intolerance. This finding also holds for the change in diastolic blood pressure in response to upright posture. In this relationship, patients with orthostatic intolerance with high plasma norepinephrine resemble those with essential hypertension, renovascular hypertension, and pheochromocytoma. We conclude that in a variety of conditions at both ends of the blood pressure spectrum, the seemingly paradoxical association of hypovolemia and diastolic blood pressure is preserved.
Publication Date: Feb 01, 1998
Document ID:
20040172777
(Acquired Dec 09, 2004)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: The American journal of the medical sciences (ISSN 0002-9629); Volume 315; 2; 95-100
Publisher Information: United States
Contract/Grant/Task Num: HL44589; RR00095
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BLOOD PRESSURE; BLOOD VOLUME; HYPOTENSION; ORTHOSTATIC TOLERANCE; POSTURE; ADRENAL GLAND; ADULTS; BLOOD; DIASTOLE; FEMALES; HYPERTENSION; MALES; NEOPLASMS; NOREPINEPHRINE; REGRESSION ANALYSIS; SYSTOLE; TUMORS; YOUTH
Other Descriptors: BLOOD PRESSURE/PHYSIOLOGY; BLOOD VOLUME/PHYSIOLOGY; HYPOTENSION, ORTHOSTATIC/PHYSIOPATHOLOGY; POSTURE; ADOLESCENT; ADRENAL GLAND NEOPLASMS/BLOOD/PHYSIOPATHOLOGY; ADULT; DIASTOLE/PHYSIOLOGY; FEMALE; HUMAN; HYPERTENSION/BLOOD/PHYSIOPATHOLOGY; HYPERTENSION, RENOVASCULAR/BLOOD/PHYSIOPATHOLOGY; MALE; NOREPINEPHRINE/BLOOD; PHEOCHROMOCYTOMA/BLOOD/PHYSIOPATHOLOGY; REGRESSION ANALYSIS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; SYSTOLE/PHYSIOLOGY; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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