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Nonlinear pattern analysis of ventricular premature beats by mutual informationThe frequency of ventricular premature beats (VPBs) has been related to the risk of mortality. However, little is known about the temporal pattern of occurrence of VPBs and its relationship to autonomic activity. Hence, we applied a general correlation measure, mutual information, to quantify how VPBs are generated over time. We also used mutual information to determine the correlation between VPB production and heart rate in order to evaluate effects of autonomic activity on VPB production. We examined twenty subjects with more than 3000 VPBs/day and simulated random time series of VPB occurrence. We found that mutual information values could be used to characterize quantitatively the temporal patterns of VPB generation. Our data suggest that VPB production is not random and VPBs generated with a higher value of mutual information may be more greatly affected by autonomic activity.
Document ID
20040172780
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Osaka, M.
(Harvard-MIT Division of Health Sciences and Technology Cambridge, MA, United States)
Saitoh, H.
Yokoshima, T.
Kishida, H.
Hayakawa, H.
Cohen, R. J.
Date Acquired
August 22, 2013
Publication Date
December 1, 1997
Publication Information
Publication: Methods of information in medicine
Volume: 36
Issue: 4-5
ISSN: 0026-1270
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center

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