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interaction of thyroid state and denervation on skeletal myosin heavy chain expressionThe goal of this study was to examine the effects of altered thyroid state and denervation (Den) on skeletal myosin heavy chain (MHC) expression in the plantaris and soleus muscles. Rats were subjected to unilateral denervation (Den) and randomly assigned to one of three groups: (1) euthyroid; (2) hyperthyroid; (3) and hypothyroid. Denervation caused severe muscle atrophy and muscle-type specific MHC transformation. Denervation transformed the soleus to a faster muscle, and its effects required the presence of circulating thyroid hormone. In contrast, denervation transformed the plantaris to a slower muscle independently of thyroid state. Furthermore, thyroid hormone effects did not depend upon innervation status in the soleus, while they required the presence of the nerve in the plantaris. Collectively, these findings suggest that both thyroid hormone and intact nerve (a) differentially affect MHC transformations in fast and slow muscle; and (b) are important factors in regulating the optimal expression of both type I and IIB MHC genes. This research suggests that for patients with nerve damage and/or paralysis, both muscle mass and biochemical properties can also be affected by the thyroid state.
Document ID
Document Type
Reprint (Version printed in journal)
Haddad, F.
(University of California at Irvine 92697-4560, United States)
Arnold, C.
Zeng, M.
Baldwin, K.
Date Acquired
August 22, 2013
Publication Date
December 1, 1997
Publication Information
Publication: Muscle & nerve
Volume: 20
Issue: 12
ISSN: 0148-639X
Subject Category
Life Sciences (General)
Funding Number(s)
Distribution Limits
NASA Discipline Musculoskeletal
Non-NASA Center