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Promethazine affects autonomic cardiovascular mechanisms minimallyPromethazine hydrochloride, Phenergan, is a phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. These properties have made promethazine a candidate for use in environments such as microgravity, which provoke emesis and motion sickness. Recently, we evaluated carotid baroreceptor-cardiac reflex responses during two Space Shuttle missions 18 to 20 hr after the 50 mg intramuscular administration of promethazine. Because the effects of promethazine on autonomic cardiovascular mechanisms in general and baroreflex function in particular were not known, we were unable to exclude a possible influence of promethazine on our results. Our purpose was to determine the ground-based effects of promethazine on autonomic cardiovascular control. Because of promethazine's antihistaminic and anticholinergic properties, we expected that a 50-mg intramuscular injection of promethazine would affect sympathetically and vagally mediated cardiovascular mechanisms. Eight healthy young subjects, five men and three women, were studied at rest in recumbency. All reported drowsiness as a result of the promethazine injection; most also reported nervous excitation, dry mouth, and fatigue. Three subjects had significant reactions: two reported excessive anxiety and one reported dizziness. Measurements were performed immediately prior to injection and 3.1 +/- 0.1 and 19.5 +/- 0.4 hr postinjection. We found no significant effect of promethazine on resting mean R-R interval, arterial pressure, R-R interval power spectra, carotid baroreflex function, and venous plasma catecholamine levels.
Document ID
20040172928
Document Type
Reprint (Version printed in journal)
Authors
Brown, T. E. (Hunter Holmes McGuire Department of Veterans Affairs Medical Center and Medical College of Virginia Richmond, United States)
Eckberg, D. L.
Date Acquired
August 22, 2013
Publication Date
August 1, 1997
Publication Information
Publication: The Journal of pharmacology and experimental therapeutics
Volume: 282
Issue: 2
ISSN: 0022-3565
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: HL22296
Distribution Limits
Public
Copyright
Other
Keywords
Clinical Trial
Non-NASA Center
NASA Discipline Cardiopulmonary